Vitamin B12 Deficiency Associated with Hashimoto and Post Radiation Encephalitis Three case reports Rubrique Article

Résumé

Vitamin B12 deficiency may complicate various neurological disorders, including autoimmune encephalitis and radiation induced brain injury, we present three cases-two involving Hashimoto encephalitis and one involving post radiotherapy leukoencephalopathy-in which severe vitamin B12 deficiency contributed to clinical deterioration.

 The first two patients were women with Hashimoto thyroiditis who presented with acute neuropsychiatric manifestations, elevated anti thyroid antibodies, and steroid responsive encephalopathy, both exhibited profound cobalamin deficiency during relapses, the third patient developed early post radiation encephalopathy one month after cranial radiotherapy, with massive reversible leukoencephalopathy and subsequently confirmed severe vitamin B12 deficiency

These observations highlight the need for systematic assessment of vitamin B12 levels in patients presenting with autoimmune or post radiation encephalopathy, as supplementation may significantly improve clinical outcomes.